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The nucleolus functions as a phase-separated protein quality control compartment. Science July 11, 2019 doi:10.1126/science.aaw9157.
Frottin F, Schueder F, Tiwary S, Gupta R, Körner R, Schlichthaerle T, Cox J, Jungmann R, Hartl FU, Hipp MS.
2019
High-quality MS/MS spectrum prediction for data-dependent and data-independent acquisition data analysis. Nat Methods. 2019 Jun;16(6):519-525. doi: 10.1038/s41592-019-0427-6. Epub 2019 May 27.
Shivani Tiwary, Roie Levy, Petra Gutenbrunner, Favio Salinas Soto, Krishnan K. Palaniappan, Laura Deming, Marc Berndl, Arthur Brant, Peter Cimermanic, Jürgen Cox.
2019
Cortical circuit alterations precede disease onset in Huntington’s disease mice. Sci Rep. 2019 Apr 29; 9(1):6634. doi: 10.1038/s41598-019-43024-w. (joint publication)
Burgold J, Schulz-Trieglaff EK, Voelkl K, Gutiérrez-Ángel S, Bader JM, Hosp F, Mann M, Arzberger T, Klein R, Liebscher S, Dudanova I.
2019
Plasma Proteome Profiling Reveals Dynamics of Inflammatory and Lipid Homeostasis Markers after Roux-En-Y Gastric Bypass Surgery. Cell Systems Dec.26, 2018. 7(6), pp.601-12.e3. doi:10.1016/j.cels.2018.10.012.
Nicolai J.Wewer Albrechtsen, Philipp E.Geyer, SophiaDoll, Peter V.Treit, Kirstine N.Bojsen-Møller, ChristofferMartinussen, Nils B.Jørgensen, Signe S.Torekov, Florian Meier, Lili Niu, Alberto Santos, Eva C.Keilhauer, Jens J.Holst, Sten Madsbad, Matthias Mann.
2018
MaxQuant goes Linux. Nat Methods. 2018 Jun;15(6):401. doi: 10.1038/s41592-018-0018-y.
Sinitcyn P., Tiwary S., Rudolph J., Gutenbrunner P., Wichmann C., Yılmaz Ş., Hamzeiy H., Salinas F., Cox J.
2018
The ER membrane protein complex interacts cotranslationally to enable biogenesis of multipass membrane proteins. ELife 2018;7:e37018; doi:10.7554/eLife.37018.
Matthew J Shurtleff, Daniel N Itzhak, Jeffrey A Hussmann, Nicole T Schirle Oakdale, Elizabeth A Costa, Martin Jonikas, Jimena Weibezahn, Katerina D Popova, Calvin H Jan, Pavel Sinitcyn, Shruthi S Vembar, Hilda Hernandez, Jürgen Cox, Alma L Burlingame, Jeffrey Brodsky, Adam Frost, Georg HH Borner, Jonathan S Weissman.
2018
Proteomics and C9orf72 neuropathology identify ribosomes as poly-GR/PR interactors driving toxicity. Published 16 May 2018. Life Science Alliance, vol1, issue2; DOI: 10.26508/lsa.201800070.
Hannelore Hartmann, Daniel Hornburg, Mareike Czuppa, Jakob Bader, Meike Michaelsen, Daniel Farny, Thomas Arzberger, Matthias Mann, Felix Meissner, Dieter Edbauer.
2018
Molecular and structural architecture of polyQ aggregates in yeast. PNAS (Mar 26, 2018), 115(15): E3446-E3453;. doi: 10.1073/pnas.1717978115 (joint publication)
A. Gruber, D. Hornburg, M. Antonin, N. Krahmer, J. Collado, M. Schaffer, G. Zubaite, C. Lüchtenborg, T. Sachsenheimer, B. Brügger, M. Mann, W. Baumeister, F.U. Hartl, M.S. Hipp and R. Fernández-Busnadiego
2018
The cryo-EM structure of huntingtin. Nature (2018), 555(7694): 117-120.; doi: 10.1038/nature25502; epub: Mar 1, 2018
Guo, B. Huang, J. Cheng, M. Seefelder, T. Engler, G. Pfeifer, P. Oeckl, M. Otto, F. Moser, M. Maurer, A. Pautsch, W. Baumeister, R. Fernández-Busnadiego and S. Kochanek
2018
In situ structure of neuronal C9orf72 poly-GA aggregates reveals proteasome recruitment. Cell (2018), Feb.8, 2018; 172(4): 696-705.e12; doi: 10.1016/j.cell.2017.12.030. (joint publication)
Q. Guo, C. Lehmer, A. Martínez-Sánchez, T. Rudack, F. Beck, H. Hartmann, M.S. Hipp, F.U. Hartl, D. Edbauer and W. Baumeister and R. Fernández-Busnadiego
2018
Spatiotemporal Proteomic Profiling of Huntington's Disease Inclusions Reveals Widespread Loss of Protein Function. Cell reports. Nov 21, 2017; 21(8): 2291-2303. doi: 10.1016/j.celrep.2017.10.097. (joint publication)
Fabian Hosp, Sara Gutiérrez-Ángel, Martin H.Schaefer, Jürgen Cox, Felix Meissner, Mark S.Hipp, F.-Ulrich Hartl, Rüdiger Klein, Irina Dudanova, Matthias Mann.
2017