The ToPAG group has held its 2nd internal retreat at Kloster Seeon in Upper Bavaria. 30 researchers involved in the project spent two busy days discussing recent progress in the various aspects of the research programme on neurodegeneration. Main topics included protein aggregation of artificial ß-sheet proteins, aggregation analysis in models for Huntington’s and Alzheimer’s disease, and methods developments – in particular regarding software for data analysis. A highlight was the evening lecture of the guest speaker Prof. Christian Griesinger (MPI of Biophysical Chemistry, Göttingen) on the interference of small DPP compounds with toxic oligomers, which inhibit neurodegeneration in animal models.
A little over two years into the project, findings obtained in different approaches start to converge. First pieces seem to fall in place in the huge puzzle of mechanisms underlying the development of neurodegenerative diseases like Huntington and Alzheimer’s. These findings also provide a basis for new collaborations in the several task forces in ToPAG, dealing with the analysis of protein aggregation in different experimental systems in vivo and in vitro.