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Department Proteomics and Signal Transduction - Prof. Matthias Mann

The Department of Proteomics and Signal Transduction (director: Matthias Mann) develops and applies methods of mass spectrometry (MS)-based proteomics in a variety of biological areas. Within the ToPAG consortium, the Mann group will perform state-of-the-art quantitative proteomic analyses to (i) investigate the composition of both soluble and insoluble protein aggregates, (ii) detect changes in the proteome during disease progression and (iii) will investigate the role of disease-critical post-translational modifications for onset and progression of several neurodegenerative diseases.

In addition, the research group of Jürgen Cox will develop new algorithms and bioinformatics tools to analyze the enormous amounts of data generated by mass spectrometry-based proteomics.

Group members:

  • Felix Meissner
    Project group leader
  • Daniel Hornburg
    PhD student
  • Fabian Hosp
  • Mario Oroshi
    Technical assistant
  • Igor Paron
    Technical assistant
  • Katharina Zettel
    Technical assistant
  • Jürgen Cox
    Research group leader
  • Arthur Carlson

More information:


International ToPAG Symposium on November 20th and 21st, 2017 - Full success!
On November 20th and 21st, ToPAG held its international Symposium on "Toxic Protein Aggregation in Neurodegeneration" at the Max Planck Institutes in Martinsried.
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TOPAG Symposium Toxic protein aggregation in neurodegeneration
November 20/21, 2017, at the MPIB, Martinsried
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Identifying Another Piece in the Parkinson's Disease Pathology Puzzle
International Consortium Identifies and Validates Cellular Role of Priority Parkinson’s Disease Drug Target, LRRK2 Kinase.
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Why nerve cells die
And what happens in a cell when Huntingtin, a protein associated with Huntington‘s disease, aggregates?
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2nd ToPAG retreat on Nov. 11/12, 2015 at Seeon/Chiemsee in Upper Bavaria
ToPAG retreat in Seeon discusses project progress
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